Letter by Virmani et al regarding article, "Drug-eluting stents in animals and patients: where do we stand today?".

Letter by Hakeem et al regarding article, "Drug-eluting or bare metal stents for the treatment of saphenous vein graft disease: a Bayesian meta-analysis".

Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents.

BACKGROUND Although effective coverage of challenging coronary lesions has warranted the use of overlapping drug-eluting stents, the histopathological response to stent overlap is unknown. METHODS AND RESULTS The arterial reaction to overlapping Cypher or Taxus drug-eluting stents was examined in rabbits with bare metal stents, BxVelocity or Express, serving as controls. Single iliac artery b...

Drug eluting stents: are human and animal studies comparable?

Animal models of stenting probably predict human responses as the stages of healing are remarkably similar. What is characteristically different is the temporal response to healing, which is substantially prolonged in humans. The prevention of restenosis in recent clinical trials of drug eluting stents may represent a near absent or incomplete phase of intimal healing. Continued long term follo...

A three-dimensional mathematical model for drug delivery from drug-eluting stents

Current drug-eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug release, more research on the <span style="font-size: 12pt; color: #000000; font-style: normal; ...

Letter regarding article by Mauri et al, "Late loss in lumen diameter and binary restenosis for drug-eluting stent comparison".

BACKGROUND Published rates of coronary restenosis have fallen below 10% in drug-eluting stent trials. Early evaluations of new stents have used continuous end points that are presumed surrogates for restenosis, but the generalizability and power of such end points have not been examined systematically. METHODS AND RESULTS We examined the relationship between incremental changes in observed la...